Low-Dose Aspirin-Induced Upper Gastrointestinal Injury-Epidemiology,Management and Prevention
نویسندگان
چکیده
Tzung-Jiun Tsai1,2 and Ping-I Hsu1,2* 1Department of Internal Medicine, Division of Gastroenterology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan 2National Yang-Ming University, Taipei, Taiwan *Corresponding author: Ping-I Hsu, Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Road, Kaohsiung 813, Taiwan, Tel: +886-7-3468233; Fax: +886-7-3468237; E-mail: [email protected]
منابع مشابه
SECONDARY PREVENTION OF UPPER GASTROINTESTINAL BLEEDING IN LOW DOSE ASPIRIN USERS INFECTED WITHHELICOBACTER PYLORI
ABSTRACT Background: Aspirin even at low dose ( 100 mg) can increase the risk of upper gastrointestinal bleeding. It is usual to use low dose aspirin for cardiovascular prophylaxis. We hypothesized that Helicobacter pylori eradication is as effective as omeprazole maintenance therapy for secondary prevention of bleeding in those who take low dose aspirin and are positive for Helicobacter pylor...
متن کاملRisk management of risk management: Combining proton pump inhibitors with low-dose aspirin
Low-dose aspirin is widely used in the primary and secondary prevention of cardiovascular events, but is associated with a range of upper gastrointestinal side effects. In this review, we summarize the rationale for low-dose aspirin therapy, quantify the risk for upper gastrointestinal side effects, identify the risk factors involved, and provide an overview of preventive strategies, thereby fo...
متن کاملPreliminary Trial of Rebamipide for Prevention of Low-Dose Aspirin-Induced Gastric Injury in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Study
Although low-dose aspirin is widely used, since it is a cheap and effective means of prevention of cardiovascular events, it can cause hemorrhagic gastrointestinal complications. The aim of this study was to evaluate the efficacy of rebamipide in preventing low-dose aspirin-induced gastric injury. A randomized, double-blind, placebo-controlled, crossover trial was performed in twenty healthy vo...
متن کاملAspirin plus esomeprazole reduced recurrent ulcer bleeding more than clopidogrel in high-risk patients.
and commentary also appear in ACP Journal Club. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . For correspondence: Dr F K Chan, Chinese University of Hong Kong, Shatin, Hong Kong, China. [email protected] Source of funding: no external funding. Clopidogrel v aspirin plus esomeprazole for patients with previous aspirin ...
متن کاملLow-dose aspirin and upper gastrointestinal bleeding in primary versus secondary cardiovascular prevention: a population-based, nested case-control study.
BACKGROUND The benefit-risk profile of low-dose aspirin in primary prevention of cardiovascular disease is unclear. We sought to quantify upper gastrointestinal bleeding (UGIB) risk associated with low-dose aspirin in secondary versus primary prevention patients. METHODS AND RESULTS We performed a population-based nested case-control study using The Health Improvement Network (THIN) Database ...
متن کامل